CPS ™ Pelletisation Technology

The CPS ™ Pelletisation Technology is a direct fluid bed pelletisation technology, originally invented by Glatt GmbH in Binzen, Germany, in 2000.

Its special features are characterized by a modified fluid bed rotor system with a conical shaped rotating disc plus additional devices for directed movement of particles. To start processing, no inert starting beads are required. Spraying of various liquids (organic and inorganic) as well as addition of dry powder are also possible. By means of rolling particles movement, CPS™ Pelletisation Technology clearly defines the densification of particles.

Typical features of CPS-pellet products are:

o Spherical and smooth pellet surfaces
o High density, low porosity
o Low attrition and friability
o Dust free surfaces
o Narrow particle size distributions, e.g. +/- 50 µm
o Yield typically > 90 %
o Wide range of mean particle sizes feasible, e.g. ~ 100 to 1400 µm

Realisation of matrix controlled modified release pellet preparations

SEM picture of a CPS extended release matrix pellet

Pro Cell™ Technology

The Pro Cell™ Technology is a fluidised bed agglomeration technology for the manufacture of very high concentrated almost spherical particles.
The ProCell fluid bed granulation process is originally performed as melt granulation process, but is now also prosecuted as aqueous or solvent based agglomeration procedure. Due to the design of the process chamber and its unique processing characteristics, drug substance loadings up to 100 % are feasible. The particle size range is adjustable over a broad size range. The agglomeration process is in particular suitable for products with inherent stickiness.

Equipment and process scheme

SEM picture of a cross-section of a ProCell active ingredient pellet, drug loading 100 %